The eu-funded NEXUS project features the development of an easily customizable, integrated and automated platform that enables Extracellular Vesicles (EVs) separation, purification and multivariate characterization from complex biofluids. Circulating EVs are vehicles of multiple categories of molecules (proteins, nucleic acids, glycans, lipids, metabolites) and represent an ideal source of diagnostic, prognostic and efficacy biomarkers for new generation of Liquid Biopsy assays, as well as supporting drug and custom care products development pipelines.
Protocol, components, system Design and Iteration, including the Proof-of-Concept of feasibility and performance of a “sample -in, result – out” system and Early and Continuous User Interaction
Development and Integration of od stand-alone separation and analytical modules into a compact, bench top, modular and automated Research Prototype Instrument. This will include determining mechanical, electrical and physical requirements for EV isolation and detection.
Optimisation and validation of work-flow and components, including the protocols, prototypes and reagents with the assessment of a cumulative analytical performance for plasma sEVs detection and subtyping, and consolidation of NEXUS platform performance using clinical samples from Prostate Cancer patients.
Refining the design and Fabrication of the integrated instrument, definition of tech-to-market, including the validation of Business Model and design of market-oriented Business Plan, and introduction of the product as an effective part of the commercial offer of the nascent Start-up.
NEXUS features the first system fully integrating the small Extracellular Vesicles (EV) isolation from complex biological samples, their controlled enrichment and release, and simultaneous multiparametric analysis.
NEXUS features the first system fully integrating the small Extracellular Vesicles (EV) isolation from complex biological samples, their controlled enrichment and release, and simultaneous multiparametric analysis.
The first instrument for EV analysis in clinical settings featuring integration of purification and analysis in a single instrument:
Unprecedent specificity and sensitivity in the analysis of protein markers
Minimal sample processing with in-line sample purification
Clinically validated for prostate cancer stratification and prognosis
Fully automated
Inorevia is an innovative company specializing in the development of advanced microfluidic platforms for complex biological protocols. Leveraging our patented Magnetic Tweezer technology and expertise in droplet microfluidics, we provide solutions that enable automation and performance improvement in life science research and diagnostics. Our flagship instrument, the Magelia, serves as a versatile platform adaptable to…
SCITEC (Institute of Chemical Sciences and Technologies “Giulio Natta”) is based in Milan and is part of the National Research Council of Italy (CNR). The Institute conducts advanced research in chemistry and materials science, focusing on the development of innovative technologies and sustainable solutions. SCITEC promotes interdisciplinary collaboration, working at the intersection of chemistry, biology,…
Nexus is organizing an in-depth workshop dedicated to exploring the role of extracellular vesicles (EVs) in liquid biopsy. The event will bring together a dynamic group of young researchers, recognized as future leaders in the field, who will engage in identifying the key challenges and requirements for the effective application of EVs in clinical diagnostics.…